The malarial metabolite hemozoin and its potential use as a vaccine adjuvant.

  title={The malarial metabolite hemozoin and its potential use as a vaccine adjuvant.},
  author={Cevayir Coban and Masanori Yagi and Keiichi Ohata and Yoshikatsu Igari and Toshihiro Tsukui and Toshihiro Horii and Ken J Ishii and Shizuo Akira},
  journal={Allergology international : official journal of the Japanese Society of Allergology},
  volume={59 2},
Hemozoin, a bio-crystalline substance, is a hemin detoxification by-product of malaria parasites. The role of hemozoin crystals in host immune system modulation by malaria parasites, and how they interact with the immune system has been enigmatic. Here, we summarize recent progress in our understanding of how hemozoin might be interacting with the host immune system. In particular, the potential application of hemozoin crystals as an adjuvant may provide insights into the molecular mechanisms… CONTINUE READING

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