The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host

@inproceedings{Coppi2011TheMC,
  title={The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host},
  author={Alida Coppi and Ramya Natarajan and Gabriele Pradel and Brandy L Bennett and Eric R. James and Mario A. Roggero and Giampietro Corradin and Cathrine E. Persson and Rita Tewari and Photini Sinnis},
  booktitle={The Journal of experimental medicine},
  year={2011}
}
Plasmodium sporozoites make a remarkable journey from the mosquito midgut to the mammalian liver. The sporozoite's major surface protein, circumsporozoite protein (CSP), is a multifunctional protein required for sporozoite development and likely mediates several steps of this journey. In this study, we show that CSP has two conformational states, an adhesive conformation in which the C-terminal cell-adhesive domain is exposed and a nonadhesive conformation in which the N terminus masks this… CONTINUE READING

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