The majority of recent short DNA insertions in the human genome are tandem duplications.

@article{Messer2007TheMO,
  title={The majority of recent short DNA insertions in the human genome are tandem duplications.},
  author={Philipp W. Messer and Peter F. Arndt},
  journal={Molecular biology and evolution},
  year={2007},
  volume={24 5},
  pages={1190-7}
}
Nucleotide substitutions, insertions, and deletions constitute the principal molecular mechanisms generating genetic variation on small length scales. In contrast to substitutions, the nature of short DNA insertions and deletions (indels) is far less understood. With the recent availability of whole-genome multiple alignments between human and other primates, detailed investigations on indel characteristics and origin have come within reach. Here, we show that the majority of short (1-100 bp… CONTINUE READING

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