The majority of endogenous microRNA targets within Alu elements avoid the microRNA machinery

@article{Hoffman2013TheMO,
  title={The majority of endogenous microRNA targets within Alu elements avoid the microRNA machinery},
  author={Yonit Hoffman and Dvir Dahary and Debora Rosa Bublik and Moshe Oren and Yitzhak Pilpel},
  journal={Bioinformatics},
  year={2013},
  volume={29 7},
  pages={894-902}
}
MOTIVATION The massive spread of repetitive elements in the human genome presents a substantial challenge to the organism, as such elements may accidentally contain seemingly functional motifs. A striking example is offered by the roughly one million copies of Alu repeats in the genome, of which ∼0.5% reside within genes' untranslated regions (UTRs), presenting ∼30 000 novel potential targets for highly conserved microRNAs (miRNAs). Here, we examine the functionality of miRNA targets within Alu… CONTINUE READING
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