The majority of CD4+8- thymocytes are functionally immature.

@article{Ramsdell1991TheMO,
  title={The majority of CD4+8- thymocytes are functionally immature.},
  author={Fred Ramsdell and Morgan Jenkins and Q. Dinh and B. J. Fowlkes},
  journal={Journal of immunology},
  year={1991},
  volume={147 6},
  pages={1779-85}
}
The thymus is the major site of T cell development and repertoire selection. During these processes, T cells segregate into two subsets that express either CD4 or CD8 accessory molecules, the phenotype of peripheral T cells. Analysis of CD4+8- thymocytes revealed that the majority of these cells express the heat-stable Ag (HSA) but not the nonclassical class I Ag, Qa-2. This HSA+, Qa-2- phenotype is similar to that of the less mature, CD4+8+ thymocytes. The remaining CD4+8- thymocytes possess… CONTINUE READING

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