The major vault protein is related to the toxic anion resistance protein (TelA) family.

@article{Suprenant2007TheMV,
  title={The major vault protein is related to the toxic anion resistance protein (TelA) family.},
  author={Kathy A. Suprenant and Nathan Bloom and Jianwen Fang and Gerald Lushington},
  journal={The Journal of experimental biology},
  year={2007},
  volume={210 Pt 6},
  pages={946-55}
}
Vaults are barrel-shaped ribonucleoprotein particles that are abundant in certain tumors and multidrug resistant cancer cells. Prokaryotic relatives of the major vault protein, MVP, have not been identified. We used sequence analysis and molecular modeling to show that MVP and the toxic anion resistance protein, TelA of Rhodobacter sphaeroides strain 2.4.1, share a novel fold that consists of a three-stranded antiparallel beta-sheet. Because of this strong structural correspondence, we examined… CONTINUE READING

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