The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling.

Abstract

The catalytic activity of the Src homology 2 (SH2) domain-containing tyrosine phosphatase, SHP-2, is required for virtually all of its signaling effects. Elucidating the molecular mechanisms of SHP-2 signaling, therefore, rests upon the identification of its target substrates. In this report, we have used SHP-2 substrate-trapping mutants to identify the… (More)

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Cite this paper

@article{Kolli2004TheMV, title={The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling.}, author={Sivanagarani Kolli and Christina Ivins Zito and Marieke H. Mossink and Erik A C Wiemer and Anton M Bennett}, journal={The Journal of biological chemistry}, year={2004}, volume={279 28}, pages={29374-85} }