The major substrates for TAP in vivo are derived from newly synthesized proteins

@article{Reits2000TheMS,
  title={The major substrates for TAP in vivo are derived from newly synthesized proteins},
  author={Eric A. J. Reits and J Chris Vos and Monique Gromm{\'e} and Jacques Neefjes},
  journal={Nature},
  year={2000},
  volume={404},
  pages={774-778}
}
The transporter associated with antigen processing (TAP) is a member of the family of ABC transporters that translocate a large variety of substrates across membranes. TAP transports peptides from the cytosol into the endoplasmic reticulum for binding to MHC class I molecules and for subsequent presentation to the immune system. Here we follow the lateral mobility of TAP in living cells. TAP's mobility increases when it is inactive and decreases when it translocates peptides. Because TAP… CONTINUE READING

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