The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes.

@article{Morel2001TheMM,
  title={The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes.},
  author={Laurence M Morel and Kim R M Blenman and Byron P. Croker and Edward K. Wakeland},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 4},
  pages={1787-92}
}
The major murine systemic lupus erythematosus (SLE) susceptibility locus Sle1 is syntenic to a chromosomal region linked with SLE susceptibility in multiple human studies. Congenic analyses have shown that Sle1 breaks tolerance to chromatin, a necessary step for full disease induction that can be suppressed by specific modifier loci. In the present study, our fine mapping analysis of the location of Sle1 has determined that three loci within this congenic interval, termed Sle1a, Sle1b, and… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
141 Citations
2 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 141 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Genes and Genetics of Autoimmunity, ed

  • P. A. Lyons, L. S. Wicker
  • 1998

Systemic Lupus Erythematosus, ed

  • R. Winchester
  • 1992

Similar Papers

Loading similar papers…