The major immediate-early gene ie3 of mouse cytomegalovirus is essential for viral growth.

@article{Angulo2000TheMI,
  title={The major immediate-early gene ie3 of mouse cytomegalovirus is essential for viral growth.},
  author={Ana Angulo and Peter Ghazal and Martin Messerle},
  journal={Journal of virology},
  year={2000},
  volume={74 23},
  pages={11129-36}
}
The significance of the major immediate-early gene ie3 of mouse cytomegalovirus (MCMV) and that of the corresponding ie2 gene of human cytomegalovirus to viral replication are not known. To investigate the function of the MCMV IE3 regulatory protein, we generated two different MCMV recombinants that contained a large deletion in the IE3 open reading frame (ORF). The mutant genomes were constructed by the bacterial artificial chromosome mutagenesis technique, and MCMV ie3 deletion mutants were… CONTINUE READING

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