The major human and mouse granzymes are structurally and functionally divergent

  title={The major human and mouse granzymes are structurally and functionally divergent},
  author={Dion Kaiserman and Catherina H. Bird and Jiuru Sun and Antony Yaron Matthews and Kheng S Ung and James C. Whisstock and Philip E. Thompson and Joseph A. Trapani and Phillip I Bird},
  journal={The Journal of Cell Biology},
  pages={619 - 630}
Approximately 2% of mammalian genes encode proteases. Comparative genomics reveals that those involved in immunity and reproduction show the most interspecies diversity and evidence of positive selection during evolution. This is particularly true of granzymes, the cytotoxic proteases of natural killer cells and CD8+ T cells. There are 5 granzyme genes in humans and 10 in mice, and it is suggested that granzymes evolve to meet species-specific immune challenge through gene duplication and more… CONTINUE READING
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