The major homology region of the HIV-1 gag precursor influences membrane affinity.

@article{EbbetsReed1996TheMH,
  title={The major homology region of the HIV-1 gag precursor influences membrane affinity.},
  author={D Ebbets-Reed and Suzanne Scarlata and Carol A. Carter},
  journal={Biochemistry},
  year={1996},
  volume={35 45},
  pages={
          14268-75
        }
}
  • D Ebbets-Reed, Suzanne Scarlata, Carol A. Carter
  • Published in Biochemistry 1996
  • Chemistry, Medicine
  • Assembly of retroviruses, including HIV-1, involves movement of newly synthesized viral proteins and RNA to the plasma membranes of host cells. The major homology region (MHR, aa 285-304), a highly conserved sequence in the capsid domain of the HIV-1 Gag precursor polyprotein, plays a critical, but unknown, role in infectious particle assembly. Mutations of invariant residues in the sequence have pleiotropic effects: Mutation of Gln287 blocks viral assembly while mutation of Arg299 permits… CONTINUE READING

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