The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I- specificity

@article{Marrack1983TheMH,
  title={The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I- specificity},
  author={Philippa Marrack and Richard Shimonkevitz and Charles Hannum and Kathryn Haskins and John W. Kappler},
  journal={The Journal of Experimental Medicine},
  year={1983},
  volume={158},
  pages={1635 - 1646}
}
In order to prove that a monoclonal antibody, KJ1-26.1, reacted with the idiotypic portion of the receptor for antigen plus major histocompatibility complex product (Ag/MHC) on the T cell hybridoma D0-11.10, 397 independent T cell hybridomas prepared from BALB/c T cells primed with ovalbumin were screened by ELISA for reactivity with the antibody. Of these T cell hybridomas one, 7D0-286, and a subclone of this hybridoma, 7D0-286.2, reacted strongly and consistently with KJ1-26.1. Further… CONTINUE READING

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A clonespecific monoclonal antibody that inhibits cytolysis of a cytolytic T cell clone

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