The major histocompatibility complex influences the ethiopathogenesis of MS-like disease in primates at multiple levels.

@article{Hart2001TheMH,
  title={The major histocompatibility complex influences the ethiopathogenesis of MS-like disease in primates at multiple levels.},
  author={Bert A 't Hart and Herbert P. M. Brok and Sandra Amor and Ronald Bontrop},
  journal={Human immunology},
  year={2001},
  volume={62 12},
  pages={
          1371-81
        }
}
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease primarily affecting the central nervous system. Of the many candidate polymorphic major histocompatibility complex (MHC) and non-MHC genes contributing to disease susceptibility, including those encoding effector (cytokines and chemokines) or receptor molecules within the immune system (MHC, TCR, Ig or FcR), human leukocyte antigen (HLA) class II genes have the most significant influence. In this article we put forward the… CONTINUE READING

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