The major genetic risk factor for severe COVID-19 is inherited from Neanderthals
@article{Zeberg2020TheMG, title={The major genetic risk factor for severe COVID-19 is inherited from Neanderthals}, author={Hugo Zeberg and Svante P{\"a}{\"a}bo}, journal={Nature}, year={2020}, pages={1-3} }
A recent genetic association study 1 identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative) 2 comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show…
264 Citations
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References
SHOWING 1-10 OF 33 REFERENCES
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
- Medicine, BiologyThe New England journal of medicine
- 2020
A 3p21.31 gene cluster is identified as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and a potential involvement of the ABO blood-group system is confirmed.
The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic
- Biology, MedicineEuropean Journal of Human Genetics
- 2020
This initiative brings together the human genetics community to generate, share, and analyze data to learn the genetic determinants of COVID-19 susceptibility, severity, and outcomes, and contribute to global knowledge of the biology of SARS-CoV-2 infection and disease.
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
- MedicineThe Lancet
- 2020
Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors
- BiologyAmerican journal of human genetics
- 2016
The landscape of Neandertal ancestry in present-day humans
- BiologyNature
- 2014
The results suggest that part of the explanation for genomic regions of reduced Neanderthal ancestry is Neanderthal alleles that caused decreased fertility in males when moved to a modern human genetic background.
A Draft Sequence of the Neandertal Genome
- BiologyScience
- 2010
The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.
The Date of Interbreeding between Neandertals and Modern Humans
- BiologyPLoS genetics
- 2012
The extent of linkage disequilibrium (LD) in the genomes of present-day Europeans is measured and it is found that the last gene flow from Neandertals (or their relatives) into Europeans likely occurred 37,000–86,000 years before the present (BP), and most likely 47,000-65,000 year ago.
A high-coverage Neandertal genome from Vindija Cave in Croatia
- BiologyScience
- 2017
The genome of a female Neandertal from ~50,000 years ago from Vindija Cave, Croatia, is sequenced to ~30-fold genomic coverage, allowing 10 to 20% more Ne andertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.
Resurrecting Surviving Neandertal Lineages from Modern Human Genomes
- BiologyScience
- 2014
Analyses of surviving archaic lineages suggest that there were fitness costs to hybridization, admixture occurred both before and after divergence of non-African modern humans, and Neandertals were a source of adaptive variation for loci involved in skin phenotypes.
The complete genome sequence of a Neandertal from the Altai Mountains
- BiologyNature
- 2014
It is shown that interbreeding, albeit of low magnitude, occurred among many hominin groups in the Late Pleistocene and a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans is established.