The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

@article{Pereyra2010TheMG,
  title={The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.},
  author={Florencia Pereyra and Xiaoming Jia and Paul J. McLaren and Amalio Telenti and Paul I W de Bakker and Bruce D. Walker and Stephan Ripke and Chanson J. Brumme and Sara L. Pulit and Mary N Carrington and Carl M. Kadie and Jonathan M. Carlson and David Heckerman and Robert R. Graham and Robert M. Plenge and Steven G. Deeks and Lauren Gianniny and Gabriel J. Crawford and Jordan Sullivan and Elena Gonzalez and Leela R L Davies and Amy L Camargo and Jamie M. Moore and Nicole L Beattie and Supriya Sen Gupta and Andrew Crenshaw and No{\"e}l P. Burtt and Candace Guiducci and Namrata Gupta and Xiaojiang Gao and Ying Qi and Yuko Yuki and Alicja Piechocka-Trocha and Emily Cutrell and Rachel L Rosenberg and Kristin L Moss and Paul Lemay and J A O'leary and Todd M. Schaefer and Pranshu Verma and Ildik{\'o} T{\'o}th and Brian L Block and Brett W Baker and Alissa C Rothchild and Jeffrey Lian and Jacqueline Proudfoot and Donna Marie L. Alvino and Seanna Vine and Marylyn Martina Addo and Todd M. Allen and Marcus Altfeld and Matthew R. Henn and Sylvie Le Gall and Hendrik Streeck and David W. Haas and Daniel R. Kuritzkes and Gregory K. Robbins and Robert W. Shafer and Roy M. Gulick and Cecilia M. Shikuma and Richard Haubrich and Sharon A. Riddler and Paul Edward Sax and Eric S Daar and Heather Ribaudo and Brian K. Agan and Shanu Agarwal and Richard L Ahern and Brady L Allen and Sherly Altidor and Eric L. Altschuler and Sujata Ambardar and Kathryn M Anastos and Ben Anderson and Val J. Anderson and Ushan Andrady and Diana Antoniskis and David R. Bangsberg and Daniel Barbaro and William Barrie and Jennifer Bartczak and Simon Barton and Patricia Basden and Nesli Basgoz and Suzane B. Bazner and Nicholaos C Bellos and Anne M Benson and Judith Berger and Nicole F Bernard and Annette M. Bernard and Christopher Birch and Stanley J. Bodner and Robert K. Bolan and Emilie T Boudreaux and Meg Bradley and James F. Braun and Jon E Brndjar and Stephen S. Brown and Katherine DeVane Brown and Sheldon Brown and Jedidiah Burack and Larry M. Bush and Virginia Cafaro and Omobolaji Campbell and John Campbell and Robert H. Carlson and J. Kevin Carmichael and Kathleen K. Casey and Chris Cavacuiti and Gregory Celestin and Steven T Chambers and Nancy Chez and Lisa M. Chirch and Paul J. Cimoch and Daniel Cohen and Lillian E. Cohn and Brian Conway and David A. Cooper and Brian Cornelson and David B T Cox and Michael V Cristofano and George J Cuchural and Julie L. Czartoski and Joseph M Dahman and Jennifer S. Daly and Benjamin T. Davis and Kristine Davis and Sheila M Davod and Edwin Dejesus and Craig Allan Dietz and Eleanor Dunham and Michael E. Dunn and Todd B Ellerin and Joseph J Eron and John J W Fangman and Claire E Farel and Helen Ferlazzo and Sarah Fidler and Anita Fleenor-Ford and Renee Frankel and Kenneth A. Freedberg and Neel K French and Jonathan D. Fuchs and J. D. Fuller and Jonna Gaberman and Joel E. Gallant and Rajesh T Gandhi and E Uruburu Garcia and Donald Garmon and Joseph Clayton Gathe and Cyril R Gaultier and Wondwoosen Gebre and Frank D Gilman and Ian Gilson and Paul A Goepfert and Michael S. Gottlieb and Claudia Goulston and Richard K Groger and T Douglas Gurley and Stuart Haber and Robin L Hardwicke and William David Hardy and P. Richard Harrigan and Trevor N Hawkins and Sonya Heath and Frederick M. Hecht and William Keith Henry and Melissa D Hladek and Robert P. Hoffman and James M Horton and Ricky K.S. Hsu and Gregory D. Huhn and Peter Hunt and Mark J Hupert and Mark L. Illeman and Hans Jaeger and Robert M. Jellinger and M. O. John and Jennifer A. Johnson and Kristin L. Johnson and Heather P Johnson and Kay Johnson and Jennifer Joly and Wilbert C. Jordan and Carol A. Kauffman and Homayoon Khanlou and Robert K Killian and Arthur Y. Kim and David Dohyung Kim and Clifford A. Kinder and Jeffrey T Kirchner and Laura Kogelman and Erna Milunka Kojic and Philip Todd Korthuis and Wayne Kurisu and Douglas S Kwon and Melissa Lamar and Harry W Lampiris and Massimiliano Lanzafame and Michael M. Lederman and David M Lee and Jean Jasmin M L Lee and Marah J. Lee and E. Ted Lee and Janice Lemoine and Jay A. Levy and Josep Mar{\'i}a Llibre and Michael A. Liguori and Susan J. Little and Anne Yenching Liu and Alvaro J. Lopez and Mono R Loutfy and Dawn Loy and Debbie Y. Mohammed and Alan J. Man and Michael K Mansour and Vincent C. Marconi and Martin Markowitz and R. F. P. Marques and Jeffrey N Martin and Harold L. Martin and Kenneth H. Mayer and M Juliana McElrath and Theresa A McGhee and Barbara Hedgis McGovern and Katherine McGowan and Dawn McIntyre and Gavin X Mcleod and Prema Menezes and Greg Mesa and Craig E. Metroka and Dirk Meyer-Olson and A. O. A. Miller and Kate Montgomery and Karam Mounzer and Ellen H Nagami and Iris Nagin and Ronald G Nahass and Margret O Nelson and Craig A Nielsen and David L Norene and David H. O'Connor and Bisola O Ojikutu and Jason F. Okulicz and Olakunle O Oladehin and Edward C. Oldfield and Susan Olender and Mario Ostrowski and William F. Owen and Eunice Pae and Jeffrey Parsonnet and Andrew M Pavlatos and Aaron M. Perlmutter and Michael N Pierce and Jonathan M. Pincus and Leandro Pisani and Lawrence Jay Price and Laurie Proia and Richard C. Prokesch and Heather Calderon Pujet and Moti N. Ramgopal and Almas Rathod and Michael J. Rausch and Jayashree Ravishankar and Frank S Rhame and Constance Shamuyarira Richards and Douglas D. Richman and Berta Rod{\'e}s and Milagros Collados Rodr{\'i}guez and Richard C. Rose and E. S. Rosenberg and D. S. H. Rosenthal and Polly E Ross and David S Rubin and Elease E Rumbaugh and Luis N. Saenz and Michelle R. Salvaggio and William Sanchez and Veeraf M Sanjana and Steven Santiago and Wolfgang Schmidt and Hanneke Schuitemaker and Philip M. Sestak and Peter Shalit and William Shay and Vivian N Shirvani and Vanessa I Silebi and James M Sizemore and Paul R. Skolnik and Marcia L Sokol-Anderson and James M. Sosman and Paul J Stabile and Jack T. Stapleton and Sheree Starrett and Francine Stein and H. -J. Stellbrink and F Lisa Sterman and Valerie E. Stone and David R. Stone and Giuseppe Tambussi and Randy Taplitz and Ellen M. Tedaldi and William Theisen and Richard Torres and Lorraine L Tosiello and C{\'e}cile Tremblay and Marc A. Tribble and Phuong D Trinh and Alice K Tsao and Peggy Ueda and Anthony J Vaccaro and Em{\'i}lia Valadas and Thanes J Vanig and Isabel Vecino and V. Martı́nez De Vega and Wenoah Veikley and Barbara H Wade and Charles M Walworth and Chingchai Wanidworanun and Douglas J Ward and Daniel A Warner and Robert D Weber and Duncan Webster and Steve Weis and David A. Wheeler and David J White and E B Wilkins and A Thomas Winston and Clifford G Wlodaver and Ang{\'e}lique B van't Wout and David P. Wright and Otto O Yang and David L Yurdin and Brandon W Zabukovic and Kimon C. Zachary and Beth Zeeman and Meng Zhao},
  journal={Science},
  year={2010},
  volume={330 6010},
  pages={
          1551-7
        }
}
Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We… CONTINUE READING
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