The major core protein of messenger ribonucleoprotein particles (p50) promotes initiation of protein biosynthesis in vitro.

@article{Evdokimova1998TheMC,
  title={The major core protein of messenger ribonucleoprotein particles (p50) promotes initiation of protein biosynthesis in vitro.},
  author={Valentina M Evdokimova and Elizaveta A. Kovrigina and Dmitri Nashchekin and Elena K. Davydova and John W. B. Hershey and Lev P. Ovchinnikov},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 6},
  pages={
          3574-81
        }
}
The major core protein of cytoplasmic messenger ribonucleoprotein particles (p50) has been shown previously to inhibit protein synthesis in vitro and in vivo. Furthermore, p50 is highly homologous to the Y-box-binding transcription factor family of proteins, binds DNA containing the Y-box motif, and thus may have a dual function in cells as a regulator of both transcription and translation. Here we show that binding or removal of p50 from rabbit reticulocyte lysate by monospecific antibodies to… CONTINUE READING
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