The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus.

@article{Glykys2007TheMS,
  title={The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus.},
  author={Joseph Glykys and Istv{\'a}n M{\'o}dy},
  journal={The Journal of physiology},
  year={2007},
  volume={582 Pt 3},
  pages={
          1163-78
        }
}
The extracellular space of the brain contains gamma-aminobutyric acid (GABA) that activates extrasynaptic GABA(A) receptors mediating tonic inhibition. The source of this GABA is uncertain: it could be overspill of vesicular release, non-vesicular leakage, reverse transport, dying cells or glia. Using a novel approach, we simultaneously measured phasic and tonic inhibitory currents and assessed their correlation. Enhancing or diminishing vesicular GABA release in hippocampal neurons caused… CONTINUE READING

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