The magnitude of thymic output is genetically determined through controlled intrathymic precursor T cell proliferation.

@article{Dulude2008TheMO,
  title={The magnitude of thymic output is genetically determined through controlled intrathymic precursor T cell proliferation.},
  author={Ga{\"e}l Dulude and R{\'e}mi Cheynier and Dominique Gauchat and A. G. Abdallah and Nadia Kettaf and Rafick Pierre S{\'e}kaly and Sophie Gratton},
  journal={Journal of immunology},
  year={2008},
  volume={181 11},
  pages={7818-24}
}
The thymus plays a crucial role in providing the immune system with naive T cells showing a diverse TCR repertoire. Whereas the diversity of thymic production is mainly ensured by TCR rearrangement at both the TRA and TRB loci, the number of cells reaching the double-positive differentiation stage defines the extent of thymic output. A quantitative analysis… CONTINUE READING