The magnitude of TCR engagement is a critical predictor of T cell anergy or activation.

@article{Mirshahidi2004TheMO,
  title={The magnitude of TCR engagement is a critical predictor of T cell anergy or activation.},
  author={Saied Mirshahidi and Laura K Ferris and Scheherazade Sadegh-Nasseri},
  journal={Journal of immunology},
  year={2004},
  volume={172 9},
  pages={
          5346-55
        }
}
Fast dissociation rate of peptide-MHC complexes from TCR has commonly been accepted to cause T cell anergy. In this study, we present evidence that peptides that form transient complexes with HLA-DR1 induce anergy in T cell clones in vitro and specific memory T cells in vivo. We demonstrate that similar to the low densities of long-lived agonist peptide-MHC, short-lived peptide-MHC ligands induce anergy by engagement of approximately 1000 TCR and activation of a similar pattern of intracellular… CONTINUE READING

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