The magnificent two: histamine and the H3 receptor as key modulators of striatal circuitry
@article{Rapanelli2017TheMT, title={The magnificent two: histamine and the H3 receptor as key modulators of striatal circuitry}, author={Maximiliano Rapanelli}, journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry}, year={2017}, volume={73}, pages={36-40} }
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References
SHOWING 1-10 OF 67 REFERENCES
Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function
- Biology, ChemistryNeuropharmacology
- 2008
Histamine H3 receptors, the complex interaction with dopamine and its implications for addiction
- Biology, PsychologyBritish journal of pharmacology
- 2013
The present review appraises the current literature on the involvement of H3 receptors in drug addiction and tries to explain these data within a theoretical framework, as well as provide suggestions for further research.
The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons*
- BiologyThe Journal of Biological Chemistry
- 2016
H3R activation with the agonist R-(-)-α-methylhistamine is found to produce a unique time- and cell type-dependent profile of molecular signaling events in the striatum, which has implications for a range of pathophysiologies.
Histamine H3 Receptor Regulates Sensorimotor Gating and Dopaminergic Signaling in the Striatum
- Biology, PsychologyThe Journal of Pharmacology and Experimental Therapeutics
- 2016
It is demonstrated that H 3R is an important regulator of sensorimotor gating, and the lack of H3R significantly modifies striatal dopaminergic signaling, which supports the usefulness of H2R ligands in neuropsychiatric disorders with preattentional deficits and disturbances in dopamine receptor–mediated signaling.
Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions
- Psychology, MedicineNeuropharmacology
- 2016
Histamine H3 receptor activation prevents dopamine D1 receptor-mediated inhibition of dopamine release in the rat striatum: A microdialysis study
- Biology, ChemistryNeuroscience Letters
- 2013
Dopamine D1-histamine H3 Receptor Heteromers Provide a Selective Link to MAPK Signaling in GABAergic Neurons of the Direct Striatal Pathway*
- Biology, ChemistryThe Journal of Biological Chemistry
- 2010
The results indicate that D1-H3 receptor heteromers work as processors integrating dopamine- and histamine-related signals involved in controlling the function of striatal neurons of the direct striatal pathway.
Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases
- Psychology, BiologyBehavioural Brain Research
- 2016