The macrophage-specific membrane protein Nramp controlling natural resistance to infections in mice has homologues expressed in the root system of plants

@article{Belouchi1995TheMM,
  title={The macrophage-specific membrane protein Nramp controlling natural resistance to infections in mice has homologues expressed in the root system of plants},
  author={Abdelmajid Belouchi and Mathieu F. M. Cellier and Tony Kwan and Hargurdeep S. Saini and Gilles D. Leroux and Philippe Gros},
  journal={Plant Molecular Biology},
  year={1995},
  volume={29},
  pages={1181-1196}
}
In mice, natural resistance or susceptibility to infection with Mycobacteria, Salmonella, and Leishmania is controlled by a gene named Bcg. Bcg regulates the capacity of macrophages to limit intracellular replication of the ingested parasites, and is believed to regulate a key bactericidal mechanism of this cell. Recently, we have cloned the Bcg gene and shown that it encodes a novel macrophage-specific membrane protein designated Nramp. A routine search of the public databases for sequences… CONTINUE READING
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