The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression

@article{Martnez2014TheMS,
  title={The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression},
  author={Vanesa Gabriela Mart{\'i}nez and Cristina Escoda-Ferran and In{\^e}s Sim{\~o}es and Satoko Arai and Marc Orta Mascar{\'o} and Esther Carreras and Mario Mart{\'i}nez-Florensa and Jos{\'e} Y{\'e}lamos and Toru Miyazaki and Francisco Lozano},
  journal={Cellular and Molecular Immunology},
  year={2014},
  volume={11},
  pages={343-354}
}
Apoptosis inhibitor of macrophages (AIMs), a homologue of human Spα, is a mouse soluble member of the scavenger receptor cysteine-rich superfamily (SRCR-SF). This family integrates a group of proteins expressed by innate and adaptive immune cells for which no unifying function has yet been described. Pleiotropic functions have been ascribed to AIM, from viability support in lymphocytes during thymic selection to lipid metabolism and anti-inflammatory effects in autoimmune pathologies. In the… CONTINUE READING