The macrophage marches on its phagosome: dynamic assays of phagosome function

@article{Russell2009TheMM,
  title={The macrophage marches on its phagosome: dynamic assays of phagosome function},
  author={David G Russell and Brian C VanderVen and Sarah Glennie and Henry Charles Mwandumba and Robert S Heyderman},
  journal={Nature Reviews Immunology},
  year={2009},
  volume={9},
  pages={594-600}
}
Professional phagocytes ingest particulate material to fulfil a diverse array of functions in a multicellular organism. The ancestral function of phagosomes is digestion; however, through evolution this degradative capacity has become pivotal to the adaptive immune response by processing antigens to be presented to lymphocytes. Moreover, phagocytes have also acquired an active role in microbial killing. This Innovation article describes new assays that probe the biological activities which… CONTINUE READING

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