The macrophage beta-glucan receptor mediates arachidonate release induced by zymosan: essential role for Src family kinases.

Abstract

Yeast-derived zymosan beads are among the classical agents used to induce sterile inflammatory responses in experimental animals and macrophage activation in cell culture. In macrophages the cytosolic phospholipase A2 becomes activated, leading to mobilization of arachidonate and the generation of prostaglandins and leukotrienes. Although zymosan can… (More)

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