The macrophage – a novel system to deliver gene therapy to pathological hypoxia

  title={The macrophage – a novel system to deliver gene therapy to pathological hypoxia},
  author={Leigh Griffiths and Katie Binley and Sharifah Iqball and On Kan and Peter Maxwell and Peter Ratcliffe and Casey A Lewis and Anjanette Harris and Susan M. Kingsman and Stuart W. Naylor},
  journal={Gene Therapy},
The use of activated macrophages in the treatment of cancer has been largely ineffectual. By ‘arming’ these cells with the ability to express a therapeutic gene we demonstrate significant advances in the efficacy of this approach. We have used a hypoxia-regulated adenoviral vector to transduce human macrophages with either a reporter or a therapeutic gene encoding human cytochrome P4502B6 (CYP2B6). Infiltration of transduced macrophages into a tumour spheroid results in induction of gene… CONTINUE READING
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