The machinery of programmed cell death.

  title={The machinery of programmed cell death.},
  author={Katja C. Zimmermann and Christine Bonzon and Douglas R Green},
  journal={Pharmacology & therapeutics},
  volume={92 1},
Apoptosis or programmed cell death is an essential physiological process that plays a critical role in development and tissue homeostasis. However, apoptosis is also involved in a wide range of pathological conditions. Apoptotic cells may be characterized by specific morphological and biochemical changes, including cell shrinkage, chromatin condensation, and internucleosomal cleavage of genomic DNA. At the molecular level, apoptosis is tightly regulated and is mainly orchestrated by the… CONTINUE READING
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