The machinery of Nod-like receptors: refining the paths to immunity and cell death.

@article{Saleh2011TheMO,
  title={The machinery of Nod-like receptors: refining the paths to immunity and cell death.},
  author={Maya Saleh},
  journal={Immunological reviews},
  year={2011},
  volume={243 1},
  pages={235-46}
}
One of the fundamental aspects of the innate immune system is its capacity to discriminate between self and non-self or altered self, and to quickly respond by eliciting effector mechanisms that act in concert to restore normalcy. This capacity is determined by a set of evolutionarily conserved pattern recognition receptors (PRRs) that sense the presence of microbial motifs or endogenous danger signals, including tissue damage, cellular transformation or metabolic perturbation, and orchestrate… CONTINUE READING

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