The machinery for endocytosis of epidermal growth factor receptor coordinates the transport of incoming hepatitis B virus to the endosomal network

@article{Iwamoto2019TheMF,
  title={The machinery for endocytosis of epidermal growth factor receptor coordinates the transport of incoming hepatitis B virus to the endosomal network},
  author={Masashi Iwamoto and Wakana Saso and Kazane Nishioka and Hirofumi Ohashi and Ryuichi Sugiyama and Akihide Ryo and Mio Ohki and Jihye Yun and Sam-Yong Park and Takayuki Ohshima and Ryosuke Suzuki and Hideki Aizaki and Masamichi Muramatsu and Tetsuro Matano and Shingo Iwami and Camille Sureau and Takaji Wakita and Koichi Watashi},
  journal={The Journal of Biological Chemistry},
  year={2019},
  volume={295},
  pages={800 - 807}
}
Sodium taurocholate cotransporting polypeptide (NTCP) is expressed at the surface of human hepatocytes and functions as an entry receptor of hepatitis B virus (HBV). Recently, we have reported that epidermal growth factor receptor (EGFR) is involved in NTCP-mediated viral internalization during the cell entry process. Here, we analyzed which function of EGFR is essential for mediating HBV internalization. In contrast to the reported crucial function of EGFR-downstream signaling for the entry of… Expand
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