The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.

@article{Banerjee1998TheMG,
  title={The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.},
  author={Anita Banerjee and Michele Sugantino and James C. Sacchettini and William Robert Jacobs},
  journal={Microbiology},
  year={1998},
  volume={144 ( Pt 10)},
  pages={2697-704}
}
A target of the anti-tuberculosis drugs isoniazid (INH) and ethionamide (ETH) has been shown to be an enoyl reductase, encoded by the inhA gene. The mabA (mycolic acid biosynthesis A) gene is located immediately upstream of inhA in Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium smegmatis. The MabA protein from M. tuberculosis was expressed in Escherichia coli and shown to have 3-ketoacyl reductase activity, consistent with a role in mycolic acid biosynthesis. In M. smegmatis… CONTINUE READING

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Program Manual: Wisconsin Sequence Analysis Package, Version 8 , UNZX

  • Genetics Computer Group
  • Madison, WI : Genetics Computer Group, Madison.
  • 1995
Highly Influential
3 Excerpts

Modification of the NADH of the isoniazid target ( InhA ) from Mycobacterium tuberculosis

  • E. F. Fritsch, T. Maniatis
  • 1998

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