The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts.

@article{Shu2009TheMC,
  title={The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts.},
  author={Lili Shu and Peter James Houghton},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 17},
  pages={4691-700}
}
Rapamycin, a selective inhibitor of mTORC1 signaling, blocks terminal myoblast differentiation. We found that downregulation of rictor, a component of the mTORC2 complex, but not downregulation of raptor, a component of the mTORC1 complex, prevented terminal differentiation (fusion) of C2C12 myoblasts. Both rapamycin and rictor downregulation suppressed the phosphorylation of AKT(S(473)), and rapamycin treatment of C2C12 myoblasts disrupted the mTORC2 complex. Importantly, downregulation of… CONTINUE READING

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