The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells.

@article{Kahn2014TheMI,
  title={The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells.},
  author={Jenna S. Kahn and Thomas J. Hayman and Muhammad Usman Jamal and Barbara Helen Rath and Tamalee R Kramp and Kevin Camphausen and Philip J. Tofilon},
  journal={Neuro-oncology},
  year={2014},
  volume={16 1},
  pages={29-37}
}
BACKGROUND The mammalian target of rapamycin (mTOR) has been suggested as a target for radiosensitization. Given that radiotherapy is a primary treatment modality for glioblastoma (GBM) and that mTOR is often dysregulated in GBM, the goal of this study was to determine the effects of AZD2014, a dual mTORC1/2 inhibitor, on the radiosensitivity of GBM stem-like cells (GSCs). METHODS mTORC1 and mTORC2 activities were defined by immunoblot analysis. The effects of this mTOR inhibitor on the in… CONTINUE READING
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