The mTOR pathway negatively controls ATM by up-regulating miRNAs.

@article{Shen2013TheMP,
  title={The mTOR pathway negatively controls ATM by up-regulating miRNAs.},
  author={Changxian Shen and Peter James Houghton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 29},
  pages={11869-74}
}
The ataxia telangiectasia mutated (ATM) checkpoint is the central surveillance system that maintains genome integrity. We found that in the context of childhood sarcoma, mammalian target of rapamycin (mTOR) signaling suppresses ATM by up-regulating miRNAs targeting ATM. Pharmacological inhibition or genetic down-regulation of the mTOR pathway resulted in increase of ATM mRNA and protein both in mouse sarcoma xenografts and cultured cells. mTOR Complex 1 (mTORC1) suppresses ATM via S6K1/2… CONTINUE READING
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ATM is down-regulated by N-Myc-regulated microRNA-421.

Proceedings of the National Academy of Sciences of the United States of America • 2010

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