The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.

@article{Delgoffe2009TheMK,
  title={The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.},
  author={Greg M. Delgoffe and T. Kole and Yan Zheng and Paul E. Zarek and Krystal L. Matthews and B. Xiao and P. Worley and S. Kozma and J. Powell},
  journal={Immunity},
  year={2009},
  volume={30 6},
  pages={
          832-44
        }
}
Effector T cell differentiation requires the simultaneous integration of multiple, and sometimes opposing, cytokine signals. We demonstrated mTOR's role in dictating the outcome of T cell fate. mTOR-deficient T cells displayed normal activation and IL-2 production upon initial stimulation. However, such cells failed to differentiate into T helper 1 (Th1), Th2, or Th17 effector cells. The inability to differentiate was associated with decreased STAT transcription factor activation and failure to… Expand
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