The mRNA nuclear export factor Hpr1 is regulated by Rsp5-mediated ubiquitylation.

@article{Gwizdek2005TheMN,
  title={The mRNA nuclear export factor Hpr1 is regulated by Rsp5-mediated ubiquitylation.},
  author={Carole Gwizdek and Maria Hobeika and Bart M Kus and Batool Ossareh-Nazari and Catherine Dargemont and Manuel S. Rodr{\'i}guez},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 14},
  pages={13401-5}
}
Ubiquitin conjugation and in particular two distinct HECT ubiquitin ligases, Rsp5p and Tom1p, have been shown to participate in the regulation of mRNA export in Saccharomyces cerevisiae. The identification of the ubiquitin ligase substrates represents a major challenge in understanding how this modification may modulate mRNA export. Here, we identified Hpr1p, a member of the THO/TREX (transcription/export) complex that couples mRNA transcription to nuclear export as a target of the ubiquitin… CONTINUE READING

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Rsp5 is required for the nuclear export of mRNA of HSF1 and MSN2/4 under stress conditions in Saccharomyces cerevisiae.

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