The mRNA export factor Npl3 mediates the nuclear export of large ribosomal subunits.

@article{Hackmann2011TheME,
  title={The mRNA export factor Npl3 mediates the nuclear export of large ribosomal subunits.},
  author={Alexandra Hackmann and Thomas Gross and Claudia Baierlein and Heike Krebber},
  journal={EMBO reports},
  year={2011},
  volume={12 10},
  pages={
          1024-31
        }
}
The nuclear export of large ribonucleoparticles is complex and requires specific transport factors. Messenger RNAs are exported through the RNA-binding protein Npl3 and the interacting export receptor Mex67. Export of large ribosomal subunits also requires Mex67; however, in this case, Mex67 binds directly to the 5S ribosomal RNA (rRNA) and does not require the Npl3 adaptor. Here, we have discovered a new function of Npl3 in mediating the export of pre-60S ribosomal subunit independently of… CONTINUE READING

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