The mRNA-binding protein HuR is regulated in the menstrual cycle and repressed in ectopic endometrium.

@article{Karipcin2011TheMP,
  title={The mRNA-binding protein HuR is regulated in the menstrual cycle and repressed in ectopic endometrium.},
  author={Fethiye Sinem Karipcin and Tuğba Altun Ensari and Umit A Kayisli and Elif E Guzel and Caleb B. Kallen and Emre Seli},
  journal={Reproductive sciences},
  year={2011},
  volume={18 2},
  pages={145-55}
}
Cytokines modulate turnover of the endometrium during the menstrual cycle and contribute to the pathogenesis of endometriosis. Gene expression for cytokines is often regulated by proteins that bind to adenosine- and uridine-rich elements (AREs) in their transcripts to stabilize or destabilize bound messenger RNAs (mRNAs). HuR/ELAVL1 is an RNA-binding protein that stabilizes ARE-containing mRNAs. We hypothesized that HuR might play a role in regulating cytokine expression during the menstrual… CONTINUE READING

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