The mPTP and its regulatory proteins: final common targets of signalling pathways for protection against necrosis.

@article{Miura2012TheMA,
  title={The mPTP and its regulatory proteins: final common targets of signalling pathways for protection against necrosis.},
  author={Tetsuji Miura and Masaya Tanno},
  journal={Cardiovascular research},
  year={2012},
  volume={94 2},
  pages={181-9}
}
The mitochondrial permeability transition pore (mPTP) is a non-selective, large-conductance channel that is closed under physiological conditions. Opening of the mPTP, leading to abolition of mitochondrial functions, is a major mechanism of myocyte necrosis by ischaemia/reperfusion, and direct inhibition of mPTP opening by use of pharmacological or genetic manipulations limits infarct size in vivo. Multiple pro-survival signal pathways commonly target the mPTP and inhibit its opening. Although… CONTINUE READING

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