The mGluR2/3 Agonist LY379268 Induced Anti-Reinstatement Effects in Rats Exhibiting Addiction-like Behavior

@article{Cannella2013TheMA,
  title={The mGluR2/3 Agonist LY379268 Induced Anti-Reinstatement Effects in Rats Exhibiting Addiction-like Behavior},
  author={Nazzareno Cannella and Briac Halbout and Stefanie Uhrig and Lionel {\'E}vrard and Mauro Corsi and Corrado Corti and V{\'e}ronique Deroche-Gamonet and Anita C Hansson and Rainer Spanagel},
  journal={Neuropsychopharmacology},
  year={2013},
  volume={38},
  pages={2048-2056}
}
Medication development for cocaine-addicted patients is difficult, and many promising preclinical candidates have failed in clinical trials. One reason for the difficulty in translating preclinical findings to the human condition is that drug testing is typically conducted in behavioral procedures in which animals do not show addiction-like traits. Recently, a DSM-IV-based animal model has been developed that allows studying the transition to an addiction-like behavior. Changes in synaptic… CONTINUE READING

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