The m74 gene product of murine cytomegalovirus (MCMV) is a functional homolog of human CMV gO and determines the entry pathway of MCMV.

@article{Scrivano2010TheMG,
  title={The m74 gene product of murine cytomegalovirus (MCMV) is a functional homolog of human CMV gO and determines the entry pathway of MCMV.},
  author={Laura Scrivano and Jasmina Esterlechner and Hermine M{\"u}hlbach and Nicole Ettischer and Christoph Hagen and Kay Gr{\"u}newald and Christian Andreas Mohr and Zsolt Ruzsics and Ulrich Η Koszinowski and Barbara Adler},
  journal={Journal of virology},
  year={2010},
  volume={84 9},
  pages={
          4469-80
        }
}
The glycoprotein gO (UL74) of human cytomegalovirus (HCMV) forms a complex with gH/gL. Virus mutants with a deletion of gO show a defect in secondary envelopment with the consequence that virus spread is restricted to a cell-associated pathway. Here we report that the positional homolog of HCMV gO, m74 of mouse CMV (MCMV), codes for a glycosylated protein which also forms a complex with gH (M75). m74 knockout mutants of MCMV show the same spread phenotype as gO knockout mutants of HCMV, namely… CONTINUE READING
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