The lytic cycle of Epstein-Barr virus is associated with decreased expression of cell surface major histocompatibility complex class I and class II molecules.

@article{Keating2002TheLC,
  title={The lytic cycle of Epstein-Barr virus is associated with decreased expression of cell surface major histocompatibility complex class I and class II molecules.},
  author={Sin{\'e}ad Keating and Stuart N Prince and Matthew H. Jones and Martin Rowe},
  journal={Journal of virology},
  year={2002},
  volume={76 16},
  pages={8179-88}
}
Human herpesviruses utilize an impressive range of strategies to evade the immune system during their lytic replicative cycle, including reducing the expression of cell surface major histocompatibility complex (MHC) and immunostimulatory molecules required for recognition and lysis by virus-specific cytotoxic T cells. Study of possible immune evasion strategies by Epstein-Barr virus (EBV) in lytically infected cells has been hampered by the lack of an appropriate permissive culture model. Using… CONTINUE READING

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