The lysosome turns fifty

@article{Duve2005TheLT,
  title={The lysosome turns fifty},
  author={C. Duve},
  journal={Nature Cell Biology},
  year={2005},
  volume={7},
  pages={847-849}
}
  • C. Duve
  • Published 2005
  • Biology
  • Nature Cell Biology
In the course of an investigation aimed at characterizing hepatic glucose 6-phosphatase, the unrelated acid phosphatase of rat liver was serendipitously observed to be latent and particle-bound in freshly prepared homogenates. Experiments designed to elucidate this intriguing finding led, 50 years ago, to the discovery of lysosomes. This could not have happened if strict adherence to a previously set programme had been mandatory. 

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