The lysosomal transport of prosaposin requires the conditional interaction of its highly conserved d domain with sphingomyelin.

Abstract

Lysosomal prosaposin (65 kDa) is a nonenzymic protein that is transported to the lysosomes in a mannose 6-phosphate-independent manner. Selective deletion of the functional domains of prosaposin indicates that the D domain and the carboxyl-terminal region are necessary for its transport to the lysosomes. Inhibitors of sphingolipid biosynthesis, such as… (More)

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@article{Lefrancois2002TheLT, title={The lysosomal transport of prosaposin requires the conditional interaction of its highly conserved d domain with sphingomyelin.}, author={Stephane Lefrancois and Taymaa May and Casey Knight and Danielle Bourbeau and Carlos Rueda Morales}, journal={The Journal of biological chemistry}, year={2002}, volume={277 19}, pages={17188-99} }