The lymphovascular embolus of inflammatory breast cancer exhibits a Notch 3 addiction

@article{Xiao2011TheLE,
  title={The lymphovascular embolus of inflammatory breast cancer exhibits a Notch 3 addiction},
  author={Y Xiao and Y Ye and Xuejing Zou and Susie Jones and Kurtis H Yearsley and Brandon S Shetuni and Joe Tellez and Sanford H. Barsky},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={287-300}
}
Inflammatory breast carcinoma (IBC) is characterized by exaggerated lymphovascular invasion (LVI), recapitulated in our human xenograft, MARY-X. This model exhibited lymphovascular emboli in vivo and corresponding spheroids in vitro. Owing to the morphological and gene profile resemblance of these spheroids to embryonal blastocysts, we wondered whether they might exhibit embryonic stem cell signaling. Specifically we investigated Notch and observed selective Notch 3 activation by expression… CONTINUE READING
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