The lymphocyte pore-forming protein perforin is associated with granules by a pH-dependent mechanism.

@article{Persechini1989TheLP,
  title={The lymphocyte pore-forming protein perforin is associated with granules by a pH-dependent mechanism.},
  author={Pedro Muanis Persechini and Chuan-ju Liu and Shibo Jiang and J. Young},
  journal={Immunology letters},
  year={1989},
  volume={22 1},
  pages={23-7}
}
A pore-forming protein (PFP, perforin or cytolysin) has been found in the cytoplasmic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Extraction of granules with high-salt buffers or by freezing-and-thawing results in the release of perforin, which occurs only when the buffer pH is above 7.0. While high-salt extraction and freezing-and-thawing of granules at low pH (below 7.0) do not result in perforin release, these treatments render granules susceptible to a… CONTINUE READING

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