The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins

@article{Aruffo1991TheLG,
  title={The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins},
  author={Alejandro Aruffo and Michael B. Melnick and Peter S. Linsley and Brian Seed},
  journal={The Journal of Experimental Medicine},
  year={1991},
  volume={174},
  pages={949 - 952}
}
The isolation, characterization, and expression of a full-length cDNA encoding the human T cell glycoprotein CD6 is described. COS cells transfected with the CD6 clone express a 90-kD protein that reacts with all available anti-CD6 monoclonal antibodies. RNA blot hybridization analysis indicates that CD6 transcripts are predominantly restricted to cells in the T lineage. The predicted CD6 sequence is 468 amino acids long, with the typical features of a type I integral membrane protein. The… CONTINUE READING