The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

@article{Bleul1996TheLC,
  title={The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry},
  author={Conrad C. Bleul and Michael Farzan and Hyeryun Choe and Cristina Parolin and I Clark-lewis and Joseph Sodroski and Timothy A. Springer},
  journal={Nature},
  year={1996},
  volume={382},
  pages={829-833}
}
  • Conrad C. Bleul, Michael Farzan, +4 authors Timothy A. Springer
  • Published in Nature 1996
  • Biology, Medicine
  • CHEMOKINES are chemotactic cytokines that activate and direct the migration of leukocytes1,2. There are two subfamilies, the CXC and the CC chemokines. We recently found that the CXC-chemokine stromal cell-derived factor-1 (SDF-1)3,4 is a highly efficacious lymphocyte chemoattractant5. Chemokines act on responsive leukocyte subsets through G-protein-coupled seven-transmembrane receptors1, which are also used by distinct strains of HIV-1 as cofactors for viral entry. Laboratory-adapted and some… CONTINUE READING

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