The lymph nodes draining the small intestine and colon are anatomically separate and immunologically distinct

@article{Houston2016TheLN,
  title={The lymph nodes draining the small intestine and colon are anatomically separate and immunologically distinct},
  author={Stephanie Houston and Vuk Cerovic and Christine D. Thomson and James Brewer and Allan McI Mowat and Simon W F Milling},
  journal={Mucosal Immunology},
  year={2016},
  volume={9},
  pages={468-478}
}
Dendritic cells (DCs) in the small intestine (SI) and colon are fundamental to direct intestinal immune responses; they migrate to the mesenteric lymph nodes (MLNs) and prime T cells. We demonstrate anatomical segregation of lymphatic drainage from the intestine, specifically that DCs from the SI and colon migrate to different nodes within the MLN, here called the sMLN and cMLN. As a consequence, different frequencies of DC subsets observed in the SI and colon are reflected among the DCs in the… CONTINUE READING

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