The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport.

@article{Trevaskis2006TheLL,
  title={The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport.},
  author={Natalie L Trevaskis and Christopher J. H. Porter and William Neil Charman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={316 2},
  pages={881-91}
}
The influence of the size and turnover kinetics of the enterocyte-based lymph lipid precursor pool (LLPP) on intestinal lymphatic drug transport has been examined. Mesenteric lymph duct-cannulated rats were infused intraduodenally with low (2-5 mg/h) or high (20 mg/h) lipid-dose formulations containing 100 microg/h halofantrine (Hf, a model drug) and 1 microCi/h (14)C-oleic acid (OA) (as a marker for lipid transport) until steady-state rates of lipid(dX(L)/dt)(ss) and drug (dD(L)/dt)(ss… CONTINUE READING

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