The lymnaea cardioexcitatory peptide (LyCEP) receptor: a G-protein-coupled receptor for a novel member of the RFamide neuropeptide family.

@article{Cox1998TheLC,
  title={The lymnaea cardioexcitatory peptide (LyCEP) receptor: a G-protein-coupled receptor for a novel member of the RFamide neuropeptide family.},
  author={Kingsley J. A. Cox and Kenneth James Cox and August B. Smit and Roel C. van der Schors and Wolfgang Meyerhof and Dorothy A. Richter and Rudi J. Planta and Petra M. Hermann and Jan van Minnen and Wijnand P. M. Geraerts and Jaco C. Knol and J. F. Burke and E. Vreugdenhil and Harm van Heerikhuizen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 23},
  pages={
          9812-21
        }
}
A novel G-protein-coupled receptor (GRL106) resembling neuropeptide Y and tachykinin receptors was cloned from the mollusc Lymnaea stagnalis. Application of a peptide extract from the Lymnaea brain to Xenopus oocytes expressing GRL106 activated a calcium-dependent chloride channel. Using this response as a bioassay, we purified the ligand for GRL106, Lymnaea cardioexcitatory peptide (LyCEP), an RFamide-type decapeptide (TPHWRPQGRF-NH2) displaying significant similarity to the Achatina… CONTINUE READING

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